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KMID : 0385920130240040453
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Journal of the Korean Society of Emergency Medicine
2013 Volume.24 No. 4 p.453 ~ p.458
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Effectiveness of Polydeoxyribonucleotide (PDRN) Material on Murine Subcutaneous Laceration Wounds
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Kim Jae-Yoon
Kim Ho-Jung
Lee Jong-Bin
Seong Soo-Dong
Cho Young-Soon
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Abstract
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Purpose: To evaluate the effectiveness of polydeoxyribonucleotide (PDRN) material on murine subcutaneous laceration wounds.
Methods: Subcutaneous laceration wounds were made on the back of mice. The mice were divided into two groups according to method of PDRN applied: Group I (control, general dressing, and management) and Group II (PDRN injection). We evaluated gross findings and histological findings for the groups.
Results: A total of 18 mice (9 in the Suture group and 9 with Suture+PDRN) were enrolled. In the mean results of gross finding (5-point Likert scale), the mean gross findings for wounds in the PDRN group were significantly higher than the suture groups on post-operative day 4 and 7 (for day 4, Suture: 2, Suture+PDRN: 3.2; for day 7, Suture: 2.7, Suture+PDRN: 4.2; p<0.05). In the histological analysis of wounds in the Suture+PDRN group after 10 days, reepithelization and granulation tissue formation were better than the Suture group. In terms of wound-healing grade, reepithelization and inflammation were not different; however, in the Suture+PDRN group, more granulation tissue formation was noted compared to the Suture group (p<0.05). In addition, the expression of VEGF in the Suture+PDRN group significantly increased compared to the Suture group (Suture: 11170【2475, Suture + PDRN: 27243【6621, p<0.05).
Conclusion: The Suture+PDRN group can be used for the early treatment and histological healing of subcutaneous laceration wounds.
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KEYWORD
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PDRN, Polydeoxyribonucleotide, Subcutaneous, Laceration, Wound
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